| Product Name | Anti-ABCB11 / BSEP Antibody [BSEP/7534] |
|---|---|
| Description | Mouse monoclonal [BSEP/7534] antibody to ABCB11 / BSEP. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | BSEP/7534 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant fragment (around Amino Acids 600-800) of human ABCB11 protein. The exact sequence is proprietary. |
| Isotype | IgG |
| Molecular Weight | 160-190 kDa |
| Target | ABCB11 / BSEP |
| Specificity | ATP-binding cassette (ABC) transporters are an evolutionarily conserved family of proteins that catalyze the transport of molecules across extra- and intracellular membranes through the energy of ATP hydrolysis. ABC genes comprise seven subfamilies, designated ABC1, Mdr/TAP, MRP, ALD, OABP, GCN20 and White. The secretion of bile salt molecules from blood into bile is a major driving force for bile formation. Bile salt export pump (BSEP) is a member of the Mdr/TAP subfamily of ABC transporters that mediates the transport of bile acids across the hepatocyte canalicular membrane and regulates bile acid-dependent bile secretion. BSEP contains putative phosphorylation sites for protein kinase A, protein kinase C (PKC) and Ca2+-calmodulin dependent kinase II, whose regulation may be dependent on bile salt concentration. |
| Reactivity | Human |
| Applications | IHC-P, WB |
| Working Dilutions | WB: 1-2 µg/ml, IHC: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide. |
| Concentration | 200 µg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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