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|Product Name||Anti-ACAT1 (clone AT15E5)|
|Description||ACAT1 (acetyl-Coenzyme A acetyltransferase 1) is a 417 amino acid protein. ACAT1 is a mitochondrial enzyme involved in the formation and degradation of ketone bodies and is necessary for the proper metabolic processing of isoleucine. ACAT1 and ACAT2 catalyze the formation of acetoacetyl-CoA from two acetyl-CoA molecules. These enzymes are also capable of the reverse reaction. Defects in ACAT1 are a cause of 3-ketothiolase deficiency. 3-ketothiolase deficiency is an inborn error of isoleucine catabolism characterized by intermittent ketoacidotic attacks associated with unconsciousness. Some patients die during an attack or are mentally retarded.|
|Applications||Dot blot, ELISA, WB|
|Clone||AT15E5. Anti-human ACAT1 mAb, clone AT2C5, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human ACAT1 protein.|
|Form||Purified, in Phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol, 0.01% Sodium Azide.|
|Immunogen||Recombinant human ACAT1 (34-427aa) purified from E. coli|
|References||Antonenkov, V.D., et al. (2000) Eur J Biochem 267: 2981-2990Korman, S.H. (2006) Mol Genet Metab 89: 289-299Yamaguchi, S., et al. (1988) J Clin Invest 81(3): 813€“817|
|Storage||Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.|
|Synonyms||Acetyl-CoA acetyltransferase 1, ACAT, MAT, T2, THIL|
|Working Dilutions||Optimal dilution should be performed by user.|
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