| Product Name | Anti-Adiponectin Antibody [ADPN/4255] |
|---|---|
| Description | Mouse monoclonal [ADPN/4255] antibody to Adiponectin. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | ADPN/4255 |
| Conjugate | Unconjugated |
| Immunogen | Synthetic peptide corresponding to the globular head region of the Adiponectin molecule. |
| Isotype | IgG1 |
| Molecular Weight | 26-30 kDa |
| Target | Adiponectin |
| Specificity | This antibody reacts with adiponectin, an adipocytokine. Adipocytokines are hormones produced in adipose tissue. Adiponectin is abundantly present in plasma and has insulin like effect on glucose levels in the blood. Plasma adiponectin levels are low in insulin resistant patients who are obese, have diabetes mellitus type 2 or HIV-lipodystrophy. In women adiponectin levels tend to be higher than in men, which may be due to androgens suppressing adiponectin levels. Furthermore, adiponectin and leptin are both indicated in regulating body weight through direct action on the hypothalamus, influencing appetite. Obese people have low adiponectin levels while levels in anorexia patients are high. Adiponectin acts as ligand for various receptors, two of which have been identified, one probably involved in carbohydrate assimilation, the other in tuning the rate of metabolism. (Hotta K, et al.) Clone ADPN/4255 is also used in a combination ELISA with clone ADPN/4256, acting as the detection antibody. |
| Reactivity | Human |
| Applications | ELISA, WB |
| Working Dilutions | WB: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide. |
| Concentration | 200 µg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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