| Product Name | Anti-Adipophilin, N-terminal, (ADRP) Polyclonal Antibody |
|---|---|
| Description | The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene. |
| Synonyms | ADFP, ADRP |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide (N-terminal aa 1-29 of human and murine adipophilin) |
| Specificity | Adipophilin is positively detected in the glandular cells of lactating mammary gland (ductal cells are negative), zona fasciculate of the adrenal gland, Sertoli cells of the testis, and in fat-accumulating hepatocytes of alcoholic cirrhotic fatty liver; adipocytes are negative. Specific detection of liposarcoma. Also positively stained are lipid-storing CD68-positive macrophages. |
| Reactivity | Bovine, Canine, Human, Mouse, Rat |
| Applications | IHC, WB |
| Form | Stabilized Serum |
| Storage | 2-8C |
| References | Heid, HW. et al. (1998) Cell Tissue Res 294: 309-321Heid, HW. et al. (1996) Biochem J. 320: 1025-1030Mrozinzki, J. et al. (1999) J. Cancer Res. & Clin. Oncol. 125: suppl.Steiner, S. et al. (1996) Biochem, Biophys Res. 218: 777-782Hope, RG & MaLauchlan, J. (2000) J. Gen. Virol. 81: 1913-1925Imamura, M. et al. (2002) Am J Physiol Endocrinol Metab 283: E775-E783Targett-Adams, P. et al. (2003) J Biol Chem, Manuscript M211289200Imai Y et al. (2007) Gastroenterology 132: 1947-1954Ohsaki, Y. et al. (2005) Histochem Cell Biol 124: 445-452Samsa MM et al. (2009) PLOS Pathogens 5(10) e1000632 |
| Background | The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene. |
| Supplier | ARP |
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