| Product Name | Anti-Adrenomedullin 1-6 Polyclonal Antibody |
|---|---|
| Description | Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in circulation control because it is found in blood in a considerable concentration. The precursor, called preproadrenomedullin, is 185 amino acids long. By RNA-blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues. Genomic ADM DNA consists of 4 exons and 3 introns, with the 5-prime flanking region containing TATA, CAAT, and GC boxes. There are also multiple binding sites for activator protein-2 and a cAMP-regulated enhancer element. |
| Synonyms | ADM, AM |
| Clonality | Polyclonal |
| Immunogen | Synthetic rat adrenomedullin 1-6, conjugated to BSA |
| Specificity | The antiserum was raised using synthetic peptides as immunogens. The antibody does not cross-react with CGRP. |
| Reactivity | Rat |
| Applications | IF, IHC |
| Form | Serum containing 0.1% sodium azide |
| Storage | 2-8C for immediate use, or at -2°C (aliquot) |
| References | Mulder, H. et al. (1996) Regulatory Peptide 62: 107-112 |
| Background | Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in circulation control because it is found in blood in a considerable concentration. The precursor, called preproadrenomedullin, is 185 amino acids long. By RNA-blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues. Genomic ADM DNA consists of 4 exons and 3 introns, with the 5-prime flanking region containing TATA, CAAT, and GC boxes. There are also multiple binding sites for activator protein-2 and a cAMP-regulated enhancer element. |
| Supplier | ARP |
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