| Product Name | Anti-ALDH1L1 Antibody [ALDH1L1/7702] - BSA and Azide free |
|---|---|
| Description | Mouse monoclonal [ALDH1L1/7702] antibody to ALDH1L1. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | ALDH1L1/7702 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant fragment of human ALDH1L1 protein. The exact sequence is proprietary. |
| Isotype | IgG |
| Molecular Weight | 99 kDa |
| Target | ALDH1L1 |
| Specificity | Aldehyde dehydrogenases (ALDHs) mediate NADP+-dependent oxidation of aldehydes into acids during detoxification of alcohol-derived acetaldehyde, lipid peroxidation and metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH1L1 (aldehyde dehydrogenase 1 family member L1), also known as FTHFD or 10-FTHFD (10-formyltetrahydrofolate dehydrogenase), is a cytosolic protein that is developmentally regulated in the cerebellum. ALDH1L1 binds to folate and catalyzes the conversion of 10-formyltetrahydrofolate (10-FTHF) to tetrahydrofolate (THF). This suggests a possible role for ALDH1L1 in the regulation of cellular THF levels as well as in the inhibition of cell proliferation (as 10-FTHF is essential for the synthesis of purine). In addition, the overexpression of ALDH1L1 can restrict cell proliferation in vitro. |
| Reactivity | Human |
| Applications | IHC-P, WB |
| Working Dilutions | WB: 1-2 µg/ml, IHC: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free. |
| Concentration | 1 mg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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