| Product Name | Anti-Aldose reductase Antibody [rAKR1B1/7295] |
|---|---|
| Description | Recombinant mouse monoclonal [rAKR1B1/7295] antibody to Aldose reductase. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | rAKR1B1/7295 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant human full-length AKR1B1 protein. |
| Isotype | IgG1 |
| Molecular Weight | 37 kDa |
| Target | Aldose reductase |
| Specificity | AKR1B1, also designated as aldose reductase, is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This protein catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. It has also been shown to have decreased expression in adrenocortical cancer, and possibly play a role in adrenal tumorigenesis. It has been suggested that AKR1B1 could be investigated as a marker of malignancy for adrenal tumor diagnosis. |
| Reactivity | Human |
| Applications | IF, IHC-P, WB |
| Working Dilutions | IF: 1-2 µg/ml, WB: 1-2 µg/ml, IHC: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide. |
| Concentration | 200 µg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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