| Product Name | Anti-Alpha, Beta - Synuclein(clone 3B6) |
|---|---|
| Description | alpha-synuclein (amino acids 119-140), an acidic neuronal protein of 140 amino acids, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. alpha-synuclein has been suggested to be implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells. Specially, the non-Abeta component of amyloid plaques is a highly amyloidogenic peptide consisting of 35 amino acids which was first identified associated with senile plaques in the Alzheimer's disease brain. |
| Synonyms | a, b - synuclein, Alpha synuclein, Beta synuclein, NACP, Non A beta component of AD amyloid, Non A4 component of amyloid precursor, PARK1, PARK4, Parkinson disease familial 1, PD1, SNCA, SNCB, SNCB protein, Synuclein alpha, Synuclein beta, |
| Host | Mouse |
| Clone | 3B6. Anti-human alpha, beta-synuclein mAb, clone 3B6, is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human alpha-synuclein protein. |
| Immunogen | Recombinant human a-synuclein (119-140aa) purified from E. coli |
| Isotype | IgG1,K |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, WB, Dot Blot |
| Form | Purified, in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide. |
| Storage | Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles. |
| References | Jakes R., et al. (1994) FEBS lett. 345, 27-32 Ueda k., et al. (1993) Proc. Natl.Acad. Sci. USA 90, 11282-11286 kim J. (1997) Molecules and Cells 7, 78-83 Paik S. R., et al. (1997) Arch. Biochem. Biophys. 344, 325-334. |
| Supplier | ARP |
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