| Product Name | Anti-alpha-Synuclein (clone AT1E10) |
|---|---|
| Description | Alpha-synuclein (amino acids 1-140), an acidic neuronal protein of 140 amino acids, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. alpha-synuclein has been suggested to be implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells. |
| Synonyms | SNCA, NACP, PARK1, alpha-Synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, Alpha synuclein, Alpha-synuclein isoform NACP140, alphaSYN, MGC105443, MGC110988, MGC127560, MGC64356, Non A beta component of AD amyloid, Non A4 component of amyloid precursor, Non-A-beta component of alzheimers disease amyloid, precursor of PARK 1, PARK 4, PARK4, Parkinson disease familial 1, PD 1, PD1, Synuclein alpha, |
| Host | Mouse |
| Clone | AT1E10. Anti-human alpha-synuclein mAb, clone AT1E10, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human alpha-synuclein protein. |
| Immunogen | Recombinant human alpha-synuclein (1-140aa) purified from E. coli |
| Isotype | IgG1,K |
| Reactivity | Human, Mouse |
| Applications | ELISA, WB, Dot Blot |
| Form | Purified, in Phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol, 0.02% Sodium Azide. |
| Storage | Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles. |
| References | Jakes, R., et al. (1994) FEBS lett. 345:27-32 Ueda, K., et al. (1993) Proc. Natl.Acad. Sci. USA 90:11282-11286 Kim, J. (1997) Molecules and Cells 7:78-83 |
| Supplier | ARP |
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