Anti-AMP Deaminase, Isoform E (AMPD3) (Erythroid Marker), Monoclonal Antibody
| Product Name | Anti-AMP Deaminase, Isoform E (AMPD3) (Erythroid Marker), Monoclonal Antibody |
|---|---|
| Description | It recognizes a protein of ~90kDa, which is identified as Adenosine Monophosphate Deaminase, isoform E (AMPD3). It has 767 amino acids and is assigned an EC 3.5.4.6. It is a highly regulated enzyme that catalyzes the hydrolytic deamination of adenosine monophosphate to inosine monophosphate, a branch point in the adenylate catabolic pathway. AMPD3 gene encodes the erythrocyte (E) isoforms, whereas other family members encode isoforms that predominate in muscle (M) and liver (L) cells. This monoclonal antibody shows reactivity with cells of the erythroid lineage at all stages of maturation in the peripheral blood, bone marrow, and fetal liver. Non-erythroid lineages are negative by flow cytometry. This monoclonal antibody is useful in the diagnosis of erythroleukemia, identification of bone marrow erythroid precursors, gating erythroid nucleated precursor cells from malignant cells in bone marrow specimens. |
| Synonyms | Adenosine monophosphate deaminase (isoform E), AMP aminohydrolase, AMP deaminase 3, AMP deaminase isoform E, Ampd3, Erythrocyte AMP deaminase, Erythrocyte specific AMP deaminase, Erythrocyte specific protein, Erythrocyte type AMP deaminase, Myoadenylate deaminase |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | AMPD3/901 |
| Immunogen | Recombinant full-length human AMDP3 protein |
| Isotype | IgG2b, kappa |
| Reactivity | Human |
| Applications | FC, ICC, IF, IHC |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 272 |
| Uniprot | Q01432 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Sabina RL, Waldenstrm A, Ronquist G. The contribution of Ca+ calmodulin activation of human erythrocyte AMP deaminase (isoform E) to the erythrocyte metabolic dysregulation of familial phosphofructokinase deficiency. Haematologica. 2006;91(5):652-5 |
| Supplier | ARP |
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