| Product Name | Anti-AMPK alpha 1 + AMPK alpha 2 Antibody [84.1] |
|---|---|
| Description | Mouse monoclonal [84.1] antibody to AMPK alpha 1 + AMPK alpha 2. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 84.1 |
| Conjugate | Unconjugated |
| Immunogen | A peptide corresponding to 29 amino acids within the N-terminal catalytic domain of Drosophila AMPK alpha. |
| Isotype | IgG2a |
| Molecular Weight | Approximately 63 kDa in rat brain cell lysates. |
| Target | AMPK alpha 1 + AMPK alpha 2 |
| Protein Length | 29 |
| Specificity | This antibody recognises both the alpha 1 and the alpha 2 isoforms of AMP-activated protein kinase (AMPK). AMPK is a highly conserved heterotrimeric protein kinase found in all eukaryotes. The heterotrimeric complex exists as multiple isoforms and consists of a catalytic alpha subunit, which is stabilized by non-catalytic regulatory beta- and gamma- subunits. AMPK plays a vital role in maintaining cellular energy homeostasis and is activated by rising levels of AMP under conditions of hypoxia, ischemia, exercise, low glucose levels.AMPK may play an important role in the control of type 2 diabetes and metabolic syndromes. AMPK functions as a suppressor of cell proliferation of both malignant and normal cells. |
| Reactivity | Vertebrate, Drosophila, Human, Mouse, Rat |
| Applications | IHC-Fr, ELISA, IF, IP, WB |
| Working Dilutions | WB: 1:100 - 1:1,000 |
| Form | Liquid |
| Diluent Buffer | Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide. |
| Concentration | 1 mg/ml |
| Storage | Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. |
| Supplier | Antibodies.com |
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