| Product Name | Anti-Amylin Polyclonal Antibody |
|---|---|
| Description | Islet, or insulinoma, amyloid polypeptide is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. While the association of amylin with the development of type II diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Studies suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes. |
| Synonyms | IAPP, DAP, IAP |
| Clonality | Polyclonal |
| Immunogen | Amylin |
| Specificity | Amylin |
| Reactivity | Feline, Guinea Pig, Human, Porcine, Rat |
| Applications | IF, IHC |
| Form | Serum containing 0.1% sodium azide |
| Storage | 2-8C for immediate use, or at -2°C (aliquot) |
| References | Mulder H et al. (1997) Peptides 18(6): 771-783Mulder H et al. (1995) Diabetologia 38: 395-402 |
| Background | Islet, or insulinoma, amyloid polypeptide is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. While the association of amylin with the development of type II diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Studies suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes. |
| Supplier | ARP |
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