| Product Name | Anti-Amyloid A Monoclonal Antibody |
|---|---|
| Description | This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11. Mab REU-86.2 is useful for the detection of AA-type amyloid and for the discrimination from other type of amyloid (AL-type and beta2M-amyloid) in human tissue biopsies. |
| Synonyms | SAA, PIG4, SAA2, TP53I4 |
| Clonality | Monoclonal |
| Clone | REU-86.2 |
| Immunogen | Human serum amyloid A (APO SAA) |
| Isotype | IgG2a |
| Specificity | REU-86.2 reacts with amyloid depositions in all organs and tissues |
| Reactivity | Human |
| Applications | ELISA, DOT |
| Form | Hybridoma culture supernatant |
| Storage | 2-8C |
| References | Linke RP et al. (1986) In: Glenner CG et al. eds. Amyloidosis, Amsterdam. Plenum Publishing Corp. pp599-605Linke RP & Huhn D. (1986) In: Glenner CG et al., eds. Amyloidosis. Amsterdam, Plenum Publishing Corp. pp79-85 |
| Background | This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11 |
| Supplier | ARP |
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