| Product Name | Anti-Androgen Receptor Monoclonal Antibody |
|---|---|
| Description | The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. The antibody is directed against the N-terminal domain of the human androgen receptor. AR is expressed e.g. in the testis, (Sertoli and Leydig cells), fibroblasts, breast epithelium, in hepatocytes and the prostate. |
| Synonyms | KD, AIS, TFM, DHTR, SBMA, HYSP1, NR3C4, SMAX1, HUMARA |
| Clonality | Monoclonal |
| Clone | F39.4 |
| Immunogen | Synthetic peptide (comprising amino acids 301-320 of human androgen receptor) |
| Isotype | IgG1 |
| Specificity | Mab F39.1 reacts with a 110 kD protein in a lysate from the LNCP cell line. It is directed against the N-terminal domain of the human androgen receptor (AR). AR is expressed e.g. in the testis (Sertoli and Leydig cells), fibroblast, breast epithelium, in hepatocytes and the prostate. Antigen localization is nuclear |
| Reactivity | Human |
| Applications | IHC, WB |
| Form | Purified, PBS with 1% BSA and 0.1% sodium azide |
| Storage | 2-8C for immediate use, or at -2°C (aliquot) |
| References | Jansen, PJ et al. (1994) J Histochem Cytochem 42: 1169-1175 |
| Background | The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. |
| Supplier | ARP |
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