| Product Name | Anti-Androgen Receptor Antibody [AR441] - BSA and Azide free |
|---|---|
| Description | Mouse monoclonal [AR441] antibody to Androgen Receptor. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | AR441 |
| Conjugate | Unconjugated |
| Immunogen | Synthetic peptide corresponding to amino acids 302-318 of human Androgen Receptor. |
| Isotype | IgG1 |
| Molecular Weight | 110 kDa |
| Target | Androgen Receptor |
| Amino Acid Sequence | STEDTAEYSPFKGGYTK |
| Specificity | This antibody recognizes a protein of 110kDa, which is identified as androgen receptor (AR). It reacts with full length, and the newly described A form of the receptor. It does not cross react with estrogen, progesterone, or glucocorticoid receptors. The expression of AR is reportedly inversely correlated with histologic grade i.e. well differentiated prostate tumors show higher expression than the poorly differentiated tumors. In prostate cancer, AR has been proposed, as a marker of hormone-responsiveness and thus it may be useful in identifying patients likely to benefit from anti-androgen therapy. Anti-androgen receptor has been useful clinically in differentiating morpheaform basal cell carcinoma (mBCC) from desmoplastic trichoepithelioma (DTE) in the skin.This MAb is superb for staining of formalin/paraffin tissues. |
| Reactivity | Human |
| Applications | FC, IF, IHC-P |
| Working Dilutions | Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, IHC-P: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free. |
| Concentration | 1 mg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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