| Product Name | Anti-Annexin A1 Antibody [CPTC-ANXA1-1] - BSA and Azide free |
|---|---|
| Description | Mouse monoclonal [CPTC-ANXA1-1] antibody to Annexin A1. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | CPTC-ANXA1-1 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant full-length human Annexin A1 protein. |
| Isotype | IgG2a |
| Molecular Weight | 38 kDa |
| Target | Annexin A1 |
| Specificity | The ANXA1 gene belongs to the annexin family, and contains 4 annexin repeats. A pair of annexin repeats may form one binding site for calcium and a phospholipid. ANXA1 promotes membrane fusion and is involved in exocytosis. The gene for ANXA1 is upregulated in hairy cell leukemia (HCL), and its protein expression is specific for HCL. Detection of ANXA1 provides a simple, highly sensitive and specific assay for diagnosing HCL. Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, suggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance. |
| Reactivity | Human |
| Applications | IHC-P, IP, WB |
| Working Dilutions | IP: 2-4 µg / mg protein, WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free. |
| Concentration | 1 mg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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