| Product Name | Anti-Anthrax Protective Antigen Antibody [C3] |
|---|---|
| Description | Mouse monoclonal [C3] antibody to Anthrax Protective Antigen. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | C3 |
| Conjugate | Unconjugated |
| Immunogen | Highly purified protective antigen of Bacillus anthracis. |
| Isotype | IgG1 |
| Target | Anthrax Protective Antigen |
| Specificity | This antibody recognises the Protective Antigen of the anthrax toxin. Bacillus anthracis produces a toxin composed of three proteins, the Protective Antigen (PA), the Edema Factor (EF) and the Lethal Factor (LF). The three proteins depend on each other for their toxic effect. Both EF and LF functions intracellularly but are too large to enter the cell through existing channels. The PA is responsible for transporting the EF and LF into cells. The 83kDa PA (PA83) binds to the cell surface where a 20 kDa N-terminal fragment (PA20) is cleaved off, exposing binding sites for LF and EF. The remaining 63 kDa portion (PA63) oligomerizes to form a heptamer pre-pore, which then associates with up to three molecules of EF and/or LF. The receptor complex is internalized within endocytotic vessels that are subsequently acidified, transforming the PA heptamer into a pore that releases the active enzymes EF (an adenylate cyclase) and LF (a protease targeting MAPKKs) into the cytosol. recognises both the 83kDa and 63kDa truncated form of PA. |
| Reactivity | Bacteria |
| Applications | ELISA, WB |
| Form | Liquid |
| Diluent Buffer | Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide. |
| Concentration | 1 mg/ml |
| Storage | Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. |
| Supplier | Antibodies.com |
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