| Product Name | Anti-APOA1 (clone AT1E12) |
|---|---|
| Description | Apolipoprotein A1 (APOA1) is the main protein component of high density lipoprotein (HDL) in plasma. This protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. Defects in APOA1 are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. High level of APOA1 is regarded as protective against atherosclerosis and cardiovascular disease. |
| Synonyms | APOA1, apolipoprotein A-I, Apolipoprotein A1, Apo-AI, ApoA-I |
| Host | Mouse |
| Clone | AT1E12. Anti-human APOA1 mAb, clone AT1E12, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human APOA1 protein. |
| Immunogen | Recombinant human APOA1 (25-267aa) purified from E. coli |
| Isotype | IgG1,K |
| Reactivity | Human, Mouse |
| Applications | ELISA, WB, Dot Blot |
| Form | Purified, in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide |
| Storage | Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles. |
| References | Dastani Z, et al. (March 2006). Atherosclerosis 185 (1): 127-36.Chiesa G, Sirtori CR (2003). Curr. Opin. Lipidol. 14 (2): 159-63.Pussinen, et al. (Jan. 1998). J. Lipid Res. (UNITED STATES) 39 (1): 152-61. |
| Supplier | ARP |
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