| Product Name | Anti-ATRX Antibody [ATRX/7188R] - BSA and Azide free |
|---|---|
| Description | Recombinant rabbit monoclonal [ATRX/7188R] antibody to ATRX. |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | ATRX/7188R |
| Conjugate | Unconjugated |
| Immunogen | Recombinant fragment (around Amino Acids 2200-2450) of human ATRX protein. The exact sequence is proprietary. |
| Isotype | IgG |
| Molecular Weight | 280 kDa |
| Target | ATRX |
| Specificity | ATRX is a member of the Snf2 family of helicase/ATPases, which contribute to the remodeling of the nucelosome structure in an ATP-dependent manner, and facilitate the initiation of transcription and replication. Structurally, ATRX contains a PHD zinc finger motif. ATRX is regulated throughout the cell cycle where it is differentially distributed within the nucleus. During interphase, ATRX predominately associates with the nuclear matrix, while during mitosis, ATRX localizes with condensed chromatin. At the onset of M phase, phosphorylation rapidly induces this redistribution of ATRX to the short arms of human acrocentric chromosomes, where it then specifically complexes with heterochromatin protein 1 thalassemia or ATRX syndrome |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free. |
| Concentration | 1 mg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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