| Product Name | Anti-B7H4 Antibody [B7H4/1788] |
|---|---|
| Description | Mouse monoclonal [B7H4/1788] antibody to B7H4. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | B7H4/1788 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant fragment of human B7-H4 protein. The exact sequence is proprietary. |
| Isotype | IgG2a |
| Molecular Weight | 35 kDa |
| Target | B7H4 |
| Specificity | T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory proteins. One such protein, B7-H4 (B7-homolog 4), belongs to the B7 immunoglobulin superfamily of ligand-lymphocyte interacting proteins. Expressed primarily on the membrane of lymphoid cells, B7-H4 is an immuno-inhibitory protein that interacts with receptors on the surface of T lymphocytes, thus mediating cellular and humoral immune responses. Overexpression of the B7-H4 protein is associated with certain malignancies, including ovarian and breast cancer, as its interaction with T cells suppresses tumor-associated immunity. Current research suggests that, similar to Mucin 16 (CA-125), B7-H4 may be a useful biomarker for the early detection of ovarian cancer. |
| Reactivity | Human |
| Applications | ELISA, FC, IF, IHC-P, WB |
| Working Dilutions | Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide. |
| Concentration | 200 µg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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