| Product Name | Anti-Basic Hair Keratin K82 (hHb2) Polyclonal Antibody |
|---|---|
| Description | The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix. |
| Synonyms | KRT82, HB2, Hb-2, KRTHB2, hHB2 |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human hair (trichocytic) keratin K82 (formerly designated keratin hHb2, SIV GTG ELY VPC EPQ GLL SC), conjugated to KLH |
| Specificity | The antiserum stains specifically human hair keratin K82 present starting from the mid bulb region in the hair cuticle (contrary to K32, expression starting from the lower part of the cuticle). |
| Reactivity | Human, Mouse |
| Applications | IHC, WB |
| Form | Stabilized Serum |
| Storage | 2-8C |
| References | Langbein, L. et al. (1999) J. Biol. Chem. 274: 19874-19893Langbein L et al. (2004) Methods in Cell V Biology 78: 413-456 |
| Background | The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix. |
| Supplier | ARP |
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