| Product Name | Anti-BCL11A Antibody [PCRP-BCL11A-1G10] |
|---|---|
| Description | Mouse monoclonal [PCRP-BCL11A-1G10] antibody to BCL11A. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | PCRP-BCL11A-1G10 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant full-length human BCLL1A protein. |
| Isotype | IgG2a |
| Molecular Weight | 91.2 kDa |
| Target | BCL11A |
| Specificity | Bcl-11a (CtIP-1, EVI9, B cell chronic lymphocytic leukemia (CLL)/lymphoma 11A) and Bcl-11b (CtIP-2, RIT1, B cell CLL/lymphoma 11B) genes play crucial roles in lymphopoiesis and influence the progression of hematopoietic malignancies. Disruption of the Bcl-11b locus is linked to T cell acute lymphoblastic leukemia, and the loss of heterozygosity in mice results in T cell lymphoma. Bcl-11 proteins are related C2H2 zinc-finger transcription factors that act as transcriptional repressors. Bcl-11b can interact with the metastasis-associated proteins MTA1 and MTA2 through the amino-terminal region. Bcl-11a is essential for postnatal development and normal lymphopoiesis. The Bcl-11a mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with Bcl-6. |
| Reactivity | Human |
| Applications | ELISA, FC, IF, IP, WB |
| Working Dilutions | WB: 1-2 µg/ml, IP: 1-2µg / 100-500µg proteins, Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide. |
| Concentration | 200 µg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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