| Product Name | Anti-BCMA Antibody [CD269/7986R] |
|---|---|
| Description | Recombinant rabbit monoclonal [CD269/7986R] antibody to BCMA. |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | CD269/7986R |
| Conjugate | Unconjugated |
| Immunogen | Recombinant human CD269 protein fragment (around Amino Acids 1-184). The exact sequence is proprietary. |
| Isotype | IgG |
| Molecular Weight | 20 kDa |
| Target | BCMA |
| Specificity | The B cell maturation protein (BCMA) is a type I integral membrane protein that belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is expressed as a 184 amino acid peptide that is expressed only in mature B-lymphocytes and is located on the cis part of the Golgi apparatus. BCMA shares significant homology with TACI (transmembrane activator) within the cysteine-rich domain. TACI has been shown to bind CAML, which induces activation of NFAT (nuclear factor of activated T cells). Both BCMA and TACI have been shown to bind APRIL and TALL-1, which stimulate B cell proliferation in conjunction with other B-cell activators. When overexpressed, TALL-1 stimulates the development of systemic lupus erythaematosus (SLE). |
| Reactivity | Human |
| Applications | ELISA, IHC-P |
| Working Dilutions | IHC: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide. |
| Concentration | 200 µg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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