| Product Name | Anti-beta 2 Microglobulin Antibody [rB2M/7279] |
|---|---|
| Description | Recombinant mouse monoclonal [rB2M/7279] antibody to beta 2 Microglobulin. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | rB2M/7279 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant full-length human B2M protein. |
| Isotype | IgG1 |
| Molecular Weight | 12 kDa |
| Target | beta 2 Microglobulin |
| Specificity | Recognizes a protein of 12kDa, identified as beta-2 microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an alpha heavy chain that contains three subdomains (alpha1, alpha2, alpha3) and a non-covalent associating light chain, known as beta-2-Microglobulin. Beta-2-Microglobulin associates with the alpha3 subdomain of the alpha heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The alpha1 and alpha2 domains of the alpha heavy chain form the peptide antigen-binding cleft. Mutations in the beta-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes. |
| Reactivity | Human, Primate |
| Applications | IHC-P |
| Working Dilutions | IHC: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide. |
| Concentration | 200 µg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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