| Product Name | Anti-Bik Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to Bik. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | A peptide corresponding to 15 amino acids from near the N-terminus of human Bik. |
| Isotype | IgG |
| Molecular Weight | Approximately 18 kDa in Jurkat cell lysates. |
| Target | Bik |
| Protein Length | 15 |
| Specificity | This antibody recognises the N-terminal region of Bcl-2-interacting killer (Bik) also known as natural born killer (Nbk). Bik is a Bcl-2 homology domain 3 (BH3)-only protein of ~18 kDa which requires the BAX gene for activation. Bik forms heterodimers with various antiapoptotic proteins such as Bcl-2 and Bcl-XL, inhibiting their antiapoptotic function. This can result in the release of Ca2+ and cytochrome C into the cytosol, leading to apoptosis.Loss of Bik is a common feature of clear-cell renal cell carcinoma (RCC), and is thought to act as a renal tissue-specific tumour suppressor gene. |
| Reactivity | Human, Mouse |
| Applications | IHC-Fr, WB |
| Working Dilutions | WB: 1 - 2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide. |
| Concentration | 1 mg/ml |
| Storage | Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. |
| Supplier | Antibodies.com |
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