| Product Name | Anti-Bim Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to Bim. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Synthetic peptide corresponding to amino acids 22-40 of human Bim. |
| Isotype | IgG |
| Molecular Weight | Approximately 22 kDa in K562 and A549 whole cell lysates. |
| Target | Bim |
| Amino Acid Sequence | AERPPQLRPGAPTSLQTEP |
| Protein Length | 19 |
| Specificity | This antibody recognises human Bcl-2 interacting mediator of cell death (Bim), also known as Bod.Bim is a pro-apoptotic protein within the Bcl-2 family, which functions within the intrinsic apotosis pathway. Bim is known to interact with pro-survival proteins including Bcl-2, Bcl-XL and Bcl-w.Bim is expressed in a variety of cell types, where it is maintained in an inactive conformation by phosphorylation or through binding to the microtubule-associated dynein motor complex. Upon certain apoptotic stimuli, Bim is released from microtubules and mediates caspase-dependent apoptosis. |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC-P, WB |
| Working Dilutions | WB: 1:1,000 |
| Form | Liquid |
| Diluent Buffer | Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide. |
| Concentration | 1 mg/ml |
| Storage | Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. |
| Supplier | Antibodies.com |
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