Anti-Blood Group Antigen H Type 2 (CD173), Monoclonal Antibody
| Product Name | Anti-Blood Group Antigen H Type 2 (CD173), Monoclonal Antibody |
|---|---|
| Description | Recognizes the blood group H type 2 antigens, trisaccharide Fuc_ ð1-2Gal_ ð1-4GlcNAc_ ð1 of human origin. This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity. It is expressed on endothelial cells, epithelial cells and granulocytes. Increased expression of this antigen has been observed on some tumor tissues such as gastric carcinomas, urothelial carcinomas, and colon carcinomas. |
| Synonyms | A transferase, ABO, B transferase, CD173, Fucosylglycoprotein 3-alpha-galactosyltransferase, Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase, Glycoprotein-fucosylgalactoside alpha-galactosyltransferase, Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase, Histo-blood group A transferase, Histo-blood group B transferase, NAGAT |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 19-OLE |
| Immunogen | Mucinous colonic adenocarcinoma |
| Isotype | IgM, kappa |
| Reactivity | Human |
| Applications | IF, IHC |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 28 |
| Uniprot | P16442 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Bara J, Daher N, Mollicone R, Oriol R. Immunohistological patterns of 20 monoclonal antibodies against non-A, non-B glycoconjugates in normal human pyloric and duodenal mucosae. Blood TransfImmunohae- matol. 1987; 30:685-692.Blood transfusion and immunohaematology, Ph Rouger, D Anstee and Ch Salmon (Eds), Arnette, France 30 (5), p. 353-720, 1987.Norwalk Virus Binds to Histo-Blood Group Antigens Present on Gastroduodenal Epithelial Cells of Secretor Individuals. SEVERINE MARIONNEAU, NATHALIE RUVOE ðN, BEATRICE LE MOULLACÐVAIDYE, MONIQUE CLEMENT, ANNE CAILLEAUÐTHOMAS, GUILLERMO RUIZÐPALACOIS, PENGWEI HUANG, XI JIANG, and JACQUES LE PENDU. GASTROENTEROLOGY 2002;122:1967Ð1977.Expression of Mucin Peptide and Blood Group ABH- and Lewis-Related Carbohydrate Antigens in Normal Human Conjunctiva. Catherine Garcher, Jacques Bara, Alain Bron, and Rafael Oriol. Invest Ophthalmol Vis Sci. 1994;35:1184-1191 |
| Supplier | ARP |
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