| Product Name | Anti-BRCA1 Antibody [BRCA1/2986] |
|---|---|
| Description | Mouse monoclonal [BRCA1/2986] antibody to BRCA1. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | BRCA1/2986 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant fragment, around amino acids 445-620, of human BRCA1 protein. The exact sequence is proprietary. |
| Isotype | IgG1 |
| Molecular Weight | 220 kDa |
| Target | BRCA1 |
| Specificity | This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. |
| Reactivity | Human |
| Applications | ELISA |
| Working Dilutions | ELISA: 2-4 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide. |
| Concentration | 200 µg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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