| Product Name | Anti-Brk / PTK6 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to Brk / PTK6. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 222-451 of human PTK6. |
| Isotype | IgG |
| Molecular Weight | Approximately 60 kDa in various cell and tissue lysates under reducing conditions |
| Target | Brk / PTK6 |
| Amino Acid Sequence | SRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERLSSFTSYENPT |
| Protein Length | 230 |
| Specificity | This antibody recognises protein-tyrosine kinase 6, also known as breast tumor kinase and tyrosine-protein kinase BRK. PTK6 is a nonreceptor tyrosine kinase that is evolutionarily related to the FRK family of kinases and more distantly to the SRC family of tyrosine kinases (Qui and Miller 2002, Brauer and Tyner 2010). It controls various signaling pathways involved in the differentiation and maintenance of normal epithelia. PTK6 substrates include AKT , SLM1 and SLM2 , STAT3 , STAT5b. PTK6 is coamplified and coexpressed with ErbB2 in human breast cancers to promote proliferation. |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| Working Dilutions | WB: 1:500 - 1:2,000 |
| Form | Liquid |
| Diluent Buffer | Supplied in Phosphate Buffered Saline with 50% Glycerol and 0.02% Sodium Azide. |
| Concentration | Lot Specific |
| Storage | Store undiluted at -20°C. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use. |
| Supplier | Antibodies.com |
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