| Product Name | Anti-c-Fos Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to c-Fos. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | A peptide corresponding to the N-terminus of human c-Fos. |
| Isotype | IgG |
| Molecular Weight | Approximately 55 kDa when run under reducing conditions |
| Target | c-Fos |
| Specificity | This antibody recognises c-Fos also known as G0/G1 switch regulatory protein 7 (G0S7). The c-Fos transcription factor is encoded by the c-Fos proto-oncogene and dimerizes with c-Jun, JDP and ATF family members to form the AP-1 transcription factor. c-Fos plays an essential role in mediating cellular signaling responses after cellular stress. The ability of the c-Fos protein to act as a transcription factor is regulated by phosphorylation on selected sites by the kinases p38, ERK, RSK1 and RSK2. The protein accumulates in the nucleus, where it acts as a transcription factor upon formation of heterodimers with c-Jun. This binding prevents the nuclear export and subsequent proteosomal degradation of c-Fos (Halazonetiset al. 1988). |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| Working Dilutions | WB: 1:200 |
| Form | Liquid |
| Diluent Buffer | Supplied in Phosphate Buffered Saline with 0.2% Gelatin and 0.1% Sodium Azide. |
| Concentration | 200 µg/ml |
| Storage | Store undiluted at 4°C. Do not freeze! Should this product contain a precipitate we recommend microcentrifugation before use. |
| Supplier | Antibodies.com |
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