| Product Name | Anti-c-Jun (phospho Ser63) Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to c-Jun (phospho Ser63). |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Phospho-specific peptide corresponding to residues surrounding Ser63 of human c-Jun. |
| Isotype | IgG |
| Target | c-Jun |
| Specificity | This antibody recognises proto-oncogene c-Jun, also known as V-jun avian sarcoma virus 17 oncogene homolog and p39, when phosphorylated at serine 63.c-Jun is a member of the Jun family of transcription factors and is a subunit of the AP-1 transcription factor. c-Jun dimerizes with c-Fos, JDP and ATF family members to form the AP-1 transcription factor. AP-1 is activated by a variety of stimuli including cytokines, stress and growth factors and plays a critical role in cellular processes ranging from proliferation to apoptosis.c-Jun is phosphorylated at serine 63 and serine 73 by MAPK8 (SAPK1/JNK1) and PLK3, resulting in c-Jun mediated transcription (Wang et al. 2007, Vleugel et al. 2006). c-Jun has been implicated in early tumor development, invasion and metastasis while c-Jun phosphorylated at serine 63 has been proposed to play a role in intestinal tumor progression. |
| Reactivity | Human |
| Applications | WB |
| Working Dilutions | WB: 1:500 - 1:2,000 |
| Form | Liquid |
| Diluent Buffer | Supplied in Phosphate Buffered Saline with 0.05% ProClin 300 and 50% Glycerol. |
| Concentration | Lot Specific |
| Storage | Store undiluted at -20°C. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use. |
| Supplier | Antibodies.com |
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