| Product Name | Anti-c-Myc (phospho Ser373) Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to c-Myc (phospho Ser373). |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Phospho-specific peptide corresponding to residues surrounding Ser373 of human c-Myc. |
| Isotype | IgG |
| Target | c-Myc |
| Specificity | This antibody recognises proto-oncogene c-Myc, also known as Class E basic helix-loop-helix protein 39, transcription factor p64 and avian myelocytomatosis viral oncogene homolog, when phosphorylated at serine 373. c-Myc is a transcription factor and a member of the Myc family of basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factors. c-Myc is involved in regulation of the cell cycle, cell differentiation and apoptosis.Dimerization of c-Myc with bHLH-Zip protein Max is necessary for transcriptional activity. c-Myc is phosphorylated at serine 373 by PAK2, this inhibits the ability of c-Myc to dimerize with Max, negatively regulating the activity of c-Myc. PKC-zeta is also reported to phosphorylate c-Myc at serine 373. |
| Reactivity | Human |
| Applications | WB |
| Working Dilutions | WB: 1:500 - 1:1,000 |
| Form | Liquid |
| Diluent Buffer | Supplied in Phosphate Buffered Saline with 50% Glycerol and 0.02% Sodium Azide. |
| Concentration | Lot Specific |
| Storage | Store undiluted at -20°C. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use. |
| Supplier | Antibodies.com |
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