| Product Name | Anti-C1QB Antibody [C1QB/2962] |
|---|---|
| Description | Mouse monoclonal [C1QB/2962] antibody to C1QB. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | C1QB/2962 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant fragment, around amino acids 41-188, of human C1QB protein. The exact sequence is proprietary. |
| Isotype | IgG |
| Molecular Weight | 26-29 kDa |
| Target | C1QB |
| Specificity | C1q, a subcomponent of the classical complement pathway, is composed of nine subunits that mediate classical complement activation and thereby play an important role in the immune response. Six of these subunits are disulfide-linked dimers of chains A and B, while three of these subunits, designated C1q-A through C1q-C, are disulfide-linked dimers of chain C. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. The presence of receptors for C1q on effector cells modulates its activity, which may be antibody-dependent or independent. Macrophages are the primary source of C1q, while anti-inflammatory drugs as well as cytokines differentially regulate expression of the mRNA as well as the protein. C1q deficiency is associated with lupus erythematosus and glomerulonephritis. |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC-P: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide. |
| Concentration | 200 µg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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