| Product Name | Anti-C3c Antibody [013E-498.2.3 (10-02A)] |
|---|---|
| Description | Mouse monoclonal [013E-498.2.3 (10-02A)] antibody to C3c. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 013E-498.2.3 (10-02A) |
| Conjugate | Unconjugated |
| Immunogen | Human C3 from normal serum, highly purified by chromatography. |
| Isotype | IgG1 |
| Target | C3c |
| Specificity | This antibody recognises the ~135 kDa complement component 3c present in serum. C3c is generated over the course of complement activation, where convertase C4b2a (classical pathway) and convertase C3bBb (alternative pathway) cleave C3 to C3b and C3a. C3b is further degraded into iC3b and C3dg/C3d. iC3b is then slowly cleaved (possibly by factor I) to form C3c (beta chain + alpha' chain fragment 1 + alpha' chain fragment 2), C3dg and C3f. C3 is crucial in the induction of tolerance generated when an antigen is introduced into immunoprivileged sites and this is exploited by pathogens and cancer cells to evade the immune system by inhibiting complement activation. |
| Reactivity | Human |
| Applications | IHC-Fr, ELISA, FC, WB |
| Form | Liquid |
| Diluent Buffer | Supplied in Borate Buffered Saline with 0.1% Sodium Azide. |
| Concentration | Lot Specific |
| Storage | Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. |
| Supplier | Antibodies.com |
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