| Product Name | Anti-C3c Antibody (FITC) |
|---|---|
| Description | Sheep polyclonal antibody to C3c (FITC). |
| Host | Sheep |
| Clonality | Polyclonal |
| Conjugate | FITC |
| Immunogen | Native human C3c purified from serum. |
| Isotype | IgG |
| Target | C3c |
| Specificity | This antibody recognises human complement 3c, a polypeptide fragment which is present in C3. C3 plays a central role in the activation of the complement system. Processing of C3 by C3 convertase is the central reaction in both classical and alternative complement pathways, resulting in C3a and C3b. C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates, and help to initiate the complement cascade, potentially resulting in cellular apoptosis. C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.C3b is rapidly split in two positions by factor I and a cofactor to form iC3b (inactivated C3b) and C3f which is released. Then iC3b is slowly cleaved (possibly by factor I) to form C3c and C3dg. Defects in C3 can result in susceptibility to pyogenic infection. This antbody shows minimal reactivity with related serum proteins. |
| Reactivity | Human |
| Applications | ELISA, IF |
| Working Dilutions | ELISA: 1:500 - 1:50K, IF: 1:10 - 1:50 |
| Form | Liquid |
| Diluent Buffer | Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide. |
| Concentration | 1 mg/ml |
| Storage | Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light. |
| Supplier | Antibodies.com |
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