| Product Name | Anti-C4c Antibody [033D-69.4.1 (10-12)] |
|---|---|
| Description | Mouse monoclonal [033D-69.4.1 (10-12)] antibody to C4c. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 033D-69.4.1 (10-12) |
| Conjugate | Unconjugated |
| Immunogen | Purified human C4c. |
| Isotype | IgG1 |
| Target | C4c |
| Specificity | This antibody recognises complement component 4c (C4c). The complement 1 complex cleaves complement 4 (C4) to form C4b and C4a. C4b levels are strictly regulated. Single site cleavage of the C4b’s alpha chain by Factor I forms iC4b and blocks C3 convertase, inhibiting opsonisation and activation of the classical pathway. iC4b is further degraded into the inactive fragments C4d and C4c. C4c consists of two a-chain fragments, alpha 4 (13 kDa) and alpha 3 (25 kDa) linked to a beta chain through disulphide bridges and a gamma chain. It is expressed in the blood plasma. |
| Reactivity | Human |
| Applications | IHC-Fr, ELISA, FC, WB |
| Form | Liquid |
| Diluent Buffer | Supplied in Borate Buffered Saline with 0.09% Sodium Azide. |
| Concentration | Lot Specific |
| Storage | Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. |
| Supplier | Antibodies.com |
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