| Product Name | Anti-C4d Antibody [057-51.5.1.6] |
|---|---|
| Description | Mouse monoclonal [057-51.5.1.6] antibody to C4d. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 057-51.5.1.6 |
| Conjugate | Unconjugated |
| Immunogen | Purified human C4d. |
| Isotype | IgG1 |
| Target | C4d |
| Specificity | This antibody recognises a neoantigen on the secreted protein complement component 4d (C4d). The complement 1 complex cleaves complement 4 (C4) to form C4b and C4a. C4b levels are strictly regulated. Single site cleavage of the C4b’s alpha chain by Factor I forms iC4b and blocks C3 convertase, inhibiting opsonisation and activation of the classical pathway. This requires C4 binding protein or CR1 as a cofactor. iC4b is further degraded into C4d and C4c. The short half life of C4d means that it is present in serum at high enough concentrations to make it a useful marker for classical complement activation.C4 has been linked to susceptibility to systemic lupus erythematosous. |
| Reactivity | Human |
| Applications | IHC-Fr, ELISA |
| Form | Liquid |
| Diluent Buffer | Supplied in Borate Buffered Saline with 0.1% Sodium Azide. |
| Concentration | Lot Specific |
| Storage | Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. |
| Supplier | Antibodies.com |
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