| Product Name | Anti-Calcitonin Antibody [CALCA/8639R] |
|---|---|
| Description | Recombinant rabbit monoclonal [CALCA/8639R] antibody to Calcitonin. |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | CALCA/8639R |
| Conjugate | Unconjugated |
| Immunogen | Recombinant fragment of human Calcitonin protein (around Amino Acids 1-141). The exact sequence is proprietary. |
| Isotype | IgG |
| Molecular Weight | 14.5 kDa |
| Target | Calcitonin |
| Specificity | Calcitonin is a 32 amino acid polypeptide hormone that preserves skeletal integrity and reduces blood calcium levels by decreasing osteoclast activity in bones, calcium and phosphate reabsorption by kidney tubules and calcium absorption by the intestines. The secretion of Calcitonin from the thyroid is regulated in part by estrogen, which increases Calcitonin mRNA levels. The Calcitonin gene, CALCA, undergoes tissue-specific RNA alternative splicing, resulting in the production of different mRNA transcripts. One transcript encodes procalcitonin as well as both calcium-lowering processed active polypeptides, Calcitonin and katacalcin. An alternative transcript of CALCA encodes the precursor for the neuropeptide referred to as Calcitonin generelated peptide 1, also designated CGRP1 or -CGRP. Mature CGRP1 and CGRP2 share significant sequence identity at the protein level differing by only 1-3 amino acid residues, depending on the species. |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC: 1:10-1:20 |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide. |
| Concentration | 200 µg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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