| Product Name | Anti-Cardiac Actin (fetal a-actin) Monoclonal Antibody |
|---|---|
| Description | Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC). Mouse Monoclonal Antibody to Cardiac Actin (fetal a-actin). Ac1 represents an excellent marker for cardiac tissue; it discriminates cardiac actin from all other actin isoforms. Polypeptide reacting: Specific for cardiac (fetal) isoform of actin. |
| Synonyms | ACTC, ASD5, CMD1R, CMH11, LVNC4 |
| Clonality | Monoclonal |
| Clone | Ac1-20.4.2 |
| Immunogen | Synthetic NH2 terminus decapeptide of cardiac isoform of actin |
| Isotype | IgG1 |
| Specificity | Fetal actin can be localized in regenerating skeletal muscle after injury (in satellite cells) and in veins of the umbilical cord. It shows no cross reactivity with other actin isoforms present in skeletal and smooth muscle, provided that stringent experimental conditions have been applied |
| Reactivity | Gallus, Bovine, Human, Rabbit |
| Applications | ELISA, IHC, WB |
| Form | Purified (Protein A), in PBS containing 1% BSA and 0.1% sodium-azide |
| Storage | 2-8C for immediate use, or at -2°C (aliquot) |
| References | Vandekerckhove, J. & Weber, K. (1979) Differentiation 14: 123-133Franke, WW et al. (1996) Differentiation 60: 245-250Rudy, DE et al. (2001) Developmental Dynamics 221: 61-71 |
| Background | Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC). |
| Supplier | ARP |
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