| Product Name | Anti-CAV1 (clone AT4C1) |
|---|---|
| Description | The identification of caveolin-1 (CAV1) as the main structural component of caveolae, together with the finding that CAV1 might serve as a molecular organizer for membrane multiprotein complexes involved in cellular traffic, endo-and transcytosis, cell adhesion and signal transduction prompted a new impulse in the research on these intracellular organells. One of the properties of CAV1 was its insolubility in cold non-ionic detergents together with apical markers in epithelial cell. Also, cholesterol is essential for caveolae formation and maintenance, and caveolae structure is highly sensitive to cholesterol depletion or treatment with cholesterol binding drugs. CAV1 tightly and specifically binds free cholesterol and artificial cholesterol containing vesicles. |
| Synonyms | VIP 21, CAV, CAV 1, CAV1, caveolae protein 22 kD, caveolin 1 alpha isoform, caveolin 1 beta isoform, Caveolin 1 caveolae protein 22kDa, Caveolin1, cell growth-inhibiting protein 32, MSTP085, OTTHUMP00000025031, VIP 21, VIP21 |
| Host | Mouse |
| Clone | AT4C1. CAV1 mAb, clone AT4C1, is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human PTS protein. |
| Immunogen | Recombinant human CAV1 (1-104aa) purified from E. coli |
| Isotype | K,IgG2b |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, WB, Dot Blot |
| Form | Purified, in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide |
| Storage | Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles. |
| References | Van Meer, G., et al. (2008) Nat Rev Mol Cell Biol. 9: 112-124 Todeschini, R.A. et al. (2008) Biochim Biophy Acta 1780: 421-433 Lajoie, P et al. (2007) J Cell Mol Med 11: 644-653 |
| Supplier | ARP |
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