| Product Name | Anti-CBFB Antibody [PCRP-CBFB-1E6] - BSA and Azide free |
|---|---|
| Description | Mouse monoclonal [PCRP-CBFB-1E6] antibody to CBFB. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | PCRP-CBFB-1E6 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant full-length human CBFB protein. |
| Isotype | IgG2a |
| Molecular Weight | 22 kDa |
| Target | CBFB |
| Specificity | The transcription factor polyomavirus enhancer binding protein 2 (PEBP2), also designated Osf2 (osteoblast-specific transcription factor), CBFA1 (core binding factor) and AML3 (acute myeloid leukemia), is composed of two subunits, α and β, which are essential for the regulation of hematopoiesis and osteogenesis. The PEBP2α subunits, PEBP2αA, PEBP2αB and PEBP2αC, are encoded by three RUNX genes, all of which contain a 128-amino acid region homologous to the highly conserved Drosophila segmentation gene, Runt. This region is involved in DNA binding and heterodimerization with the regulatory β subunit, which facilitates DNA binding of the α subunit. Both subunits are required for in vivo function; the disruption of either gene results in a lack of definitive hematopoiesis followed by embryo death in utero due to hemorrhage in the central nervous system. The gene encoding PEBP2β is the target of chromosomal inversion 16 (p13;q22) with the smooth muscle Myosin heavy chain, producing a chimeric gene, PEBP2β/CBFB-SMMHC, that is associated with human acute myeloid leukemia. |
| Reactivity | Human |
| Applications | ELISA, FC, IF, IP, WB |
| Working Dilutions | WB: 1-2 µg/ml, IP: 1-2µg / 100-500µg proteins, Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free. |
| Concentration | 1 mg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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