| Product Name | Anti-CCL23 Antibody [CCL23/4034] - BSA and Azide free |
|---|---|
| Description | Mouse monoclonal [CCL23/4034] antibody to CCL23. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | CCL23/4034 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant fragment (around Amino Acids 1-120) of human CCL23 protein. The exact sequence is proprietary. |
| Isotype | IgG2 |
| Molecular Weight | 13 kDa |
| Target | CCL23 |
| Specificity | Small inducible cytokine A23 precursor (CCL23), or CK-b-8, is a chemokine that binds to the receptor CCR1. It is involved in the immune response and inhibits production of polymorphonuclear leukocytes (PMNs) and monocytes in bone marrow. In addition, CCL23 has a splice variant, CK-b-8-1, and both variants chemoattract lymphocytes, monoctyes and neutrophils. CCL23 also promotes angiogenesis and endothelial cell migration via its actions on the CCR1 receptor. Proinflammatory proteases cleave an N-terminal domain of CCL23, improving the potency of its CCR1-mediated signaling up to 1000- fold in vitro. N-truncated CCL23 is found in high levels in synovial fluids of rheumatoid arthritis patients, suggesting a role of protease release during an inflammatory response. High levels of CCL23 mRNA expression occur in human fetal bone osteoblasts and chondrocytes, indicating a possible role for CCL23 in the recruitment of osteoclast precursors to the sites of bone reabsorption. |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC: 1-2 µg/ml |
| Form | Liquid |
| Diluent Buffer | Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free. |
| Concentration | 1 mg/ml |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Supplier | Antibodies.com |
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