| Product Name | Anti-CCR5 Antibody [T21/8] (PE) |
|---|---|
| Description | Mouse monoclonal [T21/8] antibody to CCR5 (PE). |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | T21/8 |
| Conjugate | PE |
| Immunogen | CCR5 peptide (Met1-Lys22) Keyhole Limpet Haemocyanin conjugate. |
| Isotype | IgG1 |
| Target | CCR5 |
| Specificity | This antibody recognises CD195 also known as C-C chemokine receptor 5 (CCR5) which belongs to the GPCR protein family and plays a role in inflammation by targeting cells to sites of inflammation.CD195 is expressed in a range of hematopoietic cells including macrophages, dendritic cells and memory T cells. It is also expressed by non-hematopoietic cells including vascular smooth muscle cells and astrocytes (Barmania &Pepper 2013).During inflammation CD195 expression is upregulated in CD8+ cells, allowing the cells to migrate to sites with CD4+ T cell and dendritic cell interactions. An additional well characterized feature of CD195 is its role as an essential co-receptor for macrophage tropic HIV strains, allowing the virus to enter the target cell during initial infection. This clone T28/1 has been used in flow cytometry experiments to examine expression levels in CD195 overexpressing PM1 cells. These cells were then used to examine the effect of CD195 expression levels on HIV infections. |
| Reactivity | Human |
| Applications | FC |
| Working Dilutions | Flow Cytometry: Neat, Use 10µl of the suggested working dilution to label 1x106 cells in 100µl |
| Form | Liquid |
| Diluent Buffer | Supplied in Phosphate Buffered Saline with 0.2% BSA and <0.1% Sodium Azide. |
| Concentration | Lot Specific |
| Purity | >95% (by SDS-PAGE). |
| Storage | Store undiluted at 4°C. Do not freeze! This product is photosensitive and should be protected from light. |
| Supplier | Antibodies.com |
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