Anti-CD10 (Membrane Metalloendopeptidase), Monoclonal Antibody
| Product Name | Anti-CD10 (Membrane Metalloendopeptidase), Monoclonal Antibody |
|---|---|
| Description | Recognizes a 100kDa glycoprotein, identified as CD10, also known as Common Acute Lymphocytic Leukemia Antigen (CALLA). It is a cell surface enzyme with neutral metalloendopeptidase activity, which inactivates a variety of biologically active peptides. CD10 is expressed on the cells of lymphoblastic, Burkitt_Ûªs, and follicular germinal center lymphomas, and on cells from patients with chronic myelocytic leukemia (CML). It is also expressed on the surface of normal early lymphoid progenitor cells, immature B cells within adult bone marrow and germinal center B cells within lymphoid tissue. CD10 is also present on breast myoepithelial cells, bile canaliculi, fibroblasts, with especially high expression on the brush border of kidney and gut epithelial cells. |
| Synonyms | Atriopeptidase, Common acute lymphocytic leukemia antigen (CALLA), Enkephalinase (EPN), gp100, Membrane metalloendopeptidase (MME), Neprilysin, Neutral endopeptidase (NEP), Skin fibroblast elastase (SFE) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | FR4D11 |
| Immunogen | Raji cells |
| Isotype | IgG1, kappa |
| Reactivity | Human |
| Applications | FC, IF |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 4311 |
| Uniprot | P08473 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Brown, B. et al., J. Natl. Canc. Inst, 55: 1281-1289 (1975). Tran-Paterson, R. et al., Blood, 76: 775-782 (1990) Doerken, B. et al., in Knapp, W. et. al. (eds)., Leucocyte Typing IV, Oxford Univ. Press, pp 33-34. Lavabre-Bertrand, T., et. al., Cytometry, 18: 209-217 (1994). Guerin S; et al. Cellular Immunology, 1997 Jan 10, 175(1):85-91. Guerin S; et al. Faseb Journal, 1997 Apr, 11(5):376-81 |
| Supplier | ARP |
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