Anti-CD117 / c-Kit (Marker for Gastrointestinal Stromal Tumors), Monoclonal Antibody
| Product Name | Anti-CD117 / c-Kit (Marker for Gastrointestinal Stromal Tumors), Monoclonal Antibody |
|---|---|
| Description | This monoclonal antibody recognizes a protein of 145kDa, identified as CD117/p145kit. It is found on a wide variety of tumor cells including follicular and papillary carcinoma of thyroid, adenocarcinomas from endometrium, lung, ovary, pancreas, and breast as well as malignant melanoma, endodermal sinus tumor, and small cell carcinoma. However, anti-CD117 has been particularly useful in differentiating gastrointestinal stromal tumors from Kaposiðs sarcoma, tumors of smooth muscle origin, fibromatosis, and neural tumors of the GI tract. Anti-CD117 is also useful in recognizing myeloblasts in bone marrow biopsy and clot section. |
| Synonyms | p145, Steel Factor Receptor, Stem Cell Factor Receptor (SCF-Receptor), Mast Cell Growth Factor Receptor |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | KIT/982 |
| Immunogen | Recombinant human CD117 fragment around aa100-300 |
| Isotype | IgG1, kappa |
| Reactivity | Human |
| Applications | FC, IF, IHC, WB |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 3815 |
| Uniprot | P10721 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Zafrani B, et. al. Histopathology 2000; 37(6), 536Ð545.Harvey JM, et. al. Journal of Clinical Oncology 1999; 17(5), 1474Ð1481 |
| Supplier | ARP |
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