| Product Name | Anti-CD117 c-Kit Monoclonal Antibody |
|---|---|
| Description | This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. The c-Kit proto-oncogene encodes a transmembrane receptor with tyrosine kinase activity and is closely related to the platelet-derived growth factor receptor family. Expressed in normal breast epithelium, melanocytes, mast cells, glial cells. In neoplasms the antigen is expressed in SLCC, breast carcinomas, glioblastomas, melanomas and acute/chronic myelogenous leukemias during myeloid blast crisis. Potential marker for telocytes (also described as ICLC, i.e. interstitial Cajal-like cells). |
| Synonyms | PBT, SCFR, C-Kit, CD117 |
| Clonality | Monoclonal |
| Clone | T595 |
| Immunogen | Recombinant N-terminal polypeptide (C2-like extracellular domains) |
| Isotype | IgG1 kappa |
| Specificity | In neoplasms, the antigen is expressedin SLCC, breast carcinomas, glioblastomas, melanomas and acute/chronic myelogenous leukemias during myeloid blast crisis. Mutations in C-Kit have been reported in a significant number of gastrointestinal stromaltumors (GIST). Antibodies to c-Kit are useful for differential diagnosis of GIST and other gastrointestinal tumors, e.g. smooth muscle derived neoplasms, and schwannomas. |
| Reactivity | Human |
| Applications | ICC, IHC |
| Form | Hybridoma culture Supernatant |
| Storage | 2-8C |
| References | Arber, et al. (1998) Hum Pathol 29: 498-504 |
| Background | This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Supplier | ARP |
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