Anti-CD11b / MAC-1 (Microglial Marker), Monoclonal Antibody
| Product Name | Anti-CD11b / MAC-1 (Microglial Marker), Monoclonal Antibody |
|---|---|
| Description | CD11b is a cell adhesion molecule that acts as a receptor for cell surface ligands such as intracellular adhesion molecules (ICAMs) or soluble ligands. Integrins are heterodimeric proteins that contain an a chain and b chain. Integrin ðM combines with the Integrin ?2 to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3). Integrin ðM/?2 is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. The protein CD11b has been implicated in the various adhesion-related interactions of cells such as monocytes, macrophages, natural killer (NK) cells, and granulocytes. It is part of a heterodimer that consists of CD11b and CD18. It also modulates the uptake of complement-coated particles within the cell. It is commonly used as a microglial marker in tissues derived from the nervous system. |
| Synonyms | CD11 antigen-like family member B, CD11b/CD18, CD49d, Cell surface glycoprotein MAC-1 subunit alpha, Complement Component Receptor 3 Alpha, CR3 Alpha Chain (CR3A), Integrin alpha-M, Integrin beta 2 alpha subunit, ITGAM, Leukocyte adhesion receptor MO1, Ly-40, Mac-1a, MAC1, Mac1, alpha subunit, MAC1A, Macrophage antigen alpha polypeptide, MO1A, Neutrophil adherence receptor alpha M subunit |
| Host | Rat |
| Clonality | Monoclonal |
| Clone | M1/70 |
| Immunogen | B10 mouse spleen cells enriched for T lymphocytes |
| Isotype | IgG2b, kappa |
| Reactivity | Human, Mouse, Primate, Rabbit |
| Applications | FA, FC, IF |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 3684 |
| Uniprot | P11215 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Springer T, et al. 1978. Eur. J. Immunol. 8:539. Ault K and Springer T. 1981. J. Immunol. 126:359. Springer TA, et al. 1982. Immunol. Rev. 68:171. Ho MK and Springer TA. 1983. J. Biol. Chem. 258:2766. Flotte TJ, et al. 1983. Am. J. Pathol. 111:112 |
| Supplier | ARP |
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