| Product Name | Anti-CD134 / OX40L Receptor Antibody [Ber-ACT35] |
|---|---|
| Description | Mouse monoclonal [Ber-ACT35] antibody to CD134 / OX40L Receptor. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | Ber-ACT35 |
| Conjugate | Unconjugated |
| Immunogen | HTLV 1-transformed HUT-102 cells. |
| Isotype | IgG1 |
| Target | CD134 / OX40L Receptor |
| Specificity | This antibody recognises CD134 also known as OX40 and TNFRSF4, a 50 kDa glycoprotein. CD134 is a type I transmembrane protein and a member of the tumor necrosis factor superfamily. CD134 is primarily expressed by activated T cells, although the level of expression differs according to T-cell subpopulations. OX40L also known as CD252 and TNFSF4 is the ligand of CD134. Upon ligand binding, the receptor recruits TNF receptor associated factor (TRAF) proteins which triggers downstream signaling events including NF?B pathways. This activation can regulate the number of effector T cells that accumulate in primary and secondary responses and determine the frequency of T cells that are generated (Croft 2010). Mutations affecting CD134 signaling has been linked with Kaposi sarcoma as well as susceptibility to infections. This clone Ber-ACT35 has been used in flow cytometry experiments to measure D134 expression levels on tumor-infiltrating Treg cells in mouse and human samples. |
| Reactivity | Human, Primate |
| Applications | IHC-Fr, ELISA, FC, IHC-P, IP, WB |
| Form | Liquid |
| Diluent Buffer | Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide. |
| Concentration | 1 mg/ml |
| Purity | >95% (by SDS-PAGE). |
| Storage | Store undiluted at 4°C. Do not freeze! |
| Supplier | Antibodies.com |
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