| Product Name | Anti-CD137 Antibody [4B4-1] (PE) |
|---|---|
| Description | Mouse monoclonal [4B4-1] antibody to CD137 (PE). |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 4B4-1 |
| Conjugate | PE |
| Immunogen | Recombinant human CD137 ectodomain. |
| Isotype | IgG1 |
| Target | CD137 |
| Specificity | This antibody recognises CD137. CD137 (also known as 4-1BB ligand receptor or TNFRSF9) is a type I transmembrane glycoprotein of the Tumor Necrosis Factor receptor family that is expressed on activated T and NK cells, dendritic cells, myeloid cells and at the surface of some non-lymphoid cells under specific conditions. CD137 acts as a receptor for 4-1BB ligand, expressed on activated macrophages, activated B cells, hematopoietic stem cells and myeloid progenitor cells and for some proteins of the extracellular matrix. The interaction between CD137 and 4-1BBL acts as a co-stimulatory signal for the activation, expansion and survival of T cells. CD137 signaling is involved in the generation of CD8+ T cells and enhance their cytotoxic activity. Because of its ability to promote the anti-tumorigenic activity of cytotoxic T cells, CD137 is the target of several cancer immune therapies, such as the agonist anti-CD137 Urelumab and Utomilumab. CD137 also binds to the adaptor proteins TRAF1, 2 and 3 to promote NF-kappaB activation. Mouse anti-human CD137, clone 4B4-1 has been reported to immunoprecipitate a homodimeric protein of 32kDa under reducing conditions and 85kDa under non-reducing conditions. |
| Reactivity | Human, Primate |
| Applications | FC |
| Working Dilutions | Flow Cytometry: Neat, Use 10µl of the undiluted reagent to label 1x106 cells in 100µl |
| Form | Liquid |
| Diluent Buffer | Supplied in Phosphate Buffered Saline with 0.2% BSA and <0.1% Sodium Azide. |
| Concentration | Lot Specific |
| Purity | >95% (by SDS-PAGE). |
| Storage | Store undiluted at 4°C. Do not freeze! This product is photosensitive and should be protected from light. |
| Supplier | Antibodies.com |
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