| Product Name | Anti-CD16 / Fc-gamma Receptor III, Monoclonal Antibody |
|---|---|
| Description | It recognizes CD16 (FcγRIII), the low-affinity receptor for IgG with an apparent molecular weight of 50-80kDa. Two similar genes represent CD16, CD16A (FcγRIIIA), which exists as a hetero-oligomeric polypeptide-anchored form in macrophages and NK cells and CD16B (FcγRIIIB), which exist as a monomeric GPI-anchored form in neutrophils. Furthermore, there are two known polymorphisms of CD16B, NA-1 and NA-2. Individuals homozygous for NA-2 show a lower phagocytic capacity compared with NA-1. CD16 binds IgG in the form of immune complexes and shows preferential binding of IgG1 and IgG3 isotypes and minimal binding of IgG2 and IgG4. Upon IgG binding, both CD16 isoforms initiate signal transduction cascades that lead to a variety of responses including antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, degranulation and proliferation. |
| Synonyms | FcRIIIa, FCR-10, FcRIII, FCGRIII, FcR-10, Fc fragment of IgG, low affinity IIIa, receptor for (CD16), neutrophil-specific antigen NA, CD16a, low affinity immunoglobulin gamma Fc region receptor III-A, Fc-gamma RIIIa, immunoglobulin G Fc receptor III, Fc-gamma RIII-alpha, Fc-gamma receptor IIIb (CD16), CD16a antigen, Fc-gamma receptor III-2 (CD 16), FCGR3, Fc gamma receptor III-A, FCG3, low affinity III, receptor for (CD16), Fc-gamma RIII, IGFR3FcgammaRIIIA, CD16FCRIIIA, FCRIII, Fc fragment of IgG, low affinity IIIa, receptor (CD16a) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | HO-80 |
| Immunogen | PBL s from a NK-leukemia patient |
| Isotype | IgG2a, kappa |
| Reactivity | Human |
| Applications | FA, FC, IF |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 2214 |
| Uniprot | P08637 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Knapp W. et al. (eds) Leukocyte Typing IV, Oxford University Press, Oxford, 1989. Lanier LL et al. Functional properties of a unique subset of cytotoxic CD3+ T lymphocytes that express Fc receptors for IgG (CD16/Leu-11 antigen). J Exp Med 1985, 162(6):2089-2106 |
| Supplier | ARP |
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